Taurodeoxycholate Increases the Number of Myeloid-Derived Suppressor Cells That Ameliorate Sepsis in Mice

Bile acids (BAs) control metabolism and inflammation by interacting with several receptors. Here, we report that intravenous infusion of taurodeoxycholate (TDCA) decreases serum pro-inflammatory cytokines, normalizes hypotension, protects against renal injury, and prolongs mouse survival during seps...

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Veröffentlicht in:Front Immunol
Hauptverfasser: Chang, Sooghee, Kim, Youn-Hee, Kim, Young-Joo, Kim, Young-Woo, Moon, Sungyoon, Lee, Yong Yook, Jung, Jin Sun, Kim, Youngsoo, Jung, Hi-Eun, Kim, Tae-Joo, Cheong, Taek-Chin, Moon, Hye-Jung, Cho, Jung-Ah, Kim, Hang-Rae, Han, Dohyun, Na, Yirang, Seok, Seung-Hyeok, Cho, Nam-Hyuk, Lee, Hai-Chon, Nam, Eun-Hee, Cho, Hyosuk, Choi, Murim, Minato, Nagahiro, Seong, Seung-Yong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2018
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6153344/
https://ncbi.nlm.nih.gov/pubmed/30279688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01984
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