Inhibition of DNA Methylation With Zebularine Alters Lipopolysaccharide-Induced Sickness Behavior and Neuroinflammation in Mice

Activity of DNA methyltransferases (DNMTs), the enzymes that catalyze DNA methylation, is dynamically regulated in the brain. DNMT inhibitors alter DNA methylation globally in the brain and at individual neural plasticity-associated genes, but how DNMT inhibitors centrally influence lipopolysacchari...

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Dettagli Bibliografici
Pubblicato in:Front Neurosci
Autori principali: Matt, Stephanie M., Zimmerman, Jalisa D., Lawson, Marcus A., Bustamante, Angela C., Uddin, Monica, Johnson, Rodney W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2018
Soggetti:
Neuroscience
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6153314/
https://ncbi.nlm.nih.gov/pubmed/30279646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2018.00636
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