Inhibition of DNA Methylation With Zebularine Alters Lipopolysaccharide-Induced Sickness Behavior and Neuroinflammation in Mice

Activity of DNA methyltransferases (DNMTs), the enzymes that catalyze DNA methylation, is dynamically regulated in the brain. DNMT inhibitors alter DNA methylation globally in the brain and at individual neural plasticity-associated genes, but how DNMT inhibitors centrally influence lipopolysacchari...

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Bibliografske podrobnosti
izdano v:Front Neurosci
Main Authors: Matt, Stephanie M., Zimmerman, Jalisa D., Lawson, Marcus A., Bustamante, Angela C., Uddin, Monica, Johnson, Rodney W.
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2018
Teme:
Neuroscience
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6153314/
https://ncbi.nlm.nih.gov/pubmed/30279646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2018.00636
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