Inhibition of DNA Methylation With Zebularine Alters Lipopolysaccharide-Induced Sickness Behavior and Neuroinflammation in Mice

Activity of DNA methyltransferases (DNMTs), the enzymes that catalyze DNA methylation, is dynamically regulated in the brain. DNMT inhibitors alter DNA methylation globally in the brain and at individual neural plasticity-associated genes, but how DNMT inhibitors centrally influence lipopolysacchari...

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Detalhes bibliográficos
Publicado no:Front Neurosci
Main Authors: Matt, Stephanie M., Zimmerman, Jalisa D., Lawson, Marcus A., Bustamante, Angela C., Uddin, Monica, Johnson, Rodney W.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6153314/
https://ncbi.nlm.nih.gov/pubmed/30279646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2018.00636
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