Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia

BACKGROUND: Activation of the peripheral innate immune system stimulates the secretion of CNS cytokines that modulate the behavioral symptoms of sickness. Excessive production of cytokines by microglia, however, may cause long-lasting behavioral and cognitive complications. The purpose of this study...

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Detalhes bibliográficos
Main Authors: Henry, Christopher J, Huang, Yan, Wynne, Angela, Hanke, Mark, Himler, Justin, Bailey, Michael T, Sheridan, John F, Godbout, Jonathan P
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2008
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2412862/
https://ncbi.nlm.nih.gov/pubmed/18477398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-5-15
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