Combination of ATO with FLT3 TKIs eliminates FLT3/ITD+ leukemia cells through reduced expression of FLT3

Acute myeloid leukemia (AML) patients with FLT3/ITD mutations have a poor prognosis. Monotherapy with selective FLT3 tyrosine kinase inhibitors (TKIs) have shown transient and limited efficacy due to the development of resistance. Arsenic trioxide (ATO, As(2)O(3)) has been proven effective in treati...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Nagai, Kozo, Hou, Lihong, Li, Li, Nguyen, Bao, Seale, Tessa, Shirley, Courtney, Ma, Hayley, Levis, Mark, Ghiaur, Gabriel, Duffield, Amy, Small, Donald
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2018
Fag:
Priority Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6152471/
https://ncbi.nlm.nih.gov/pubmed/30250637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25972
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