Codon misreading tRNAs promote tumor growth in mice

Deregulation of tRNAs, aminoacyl-tRNA synthetases and tRNA modifying enzymes are common in cancer, raising the hypothesis that protein synthesis efficiency and accuracy (mistranslation) are compromised in tumors. We show here that human colon tumors and xenograft tumors produced in mice by two epith...

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Veröffentlicht in:RNA Biol
Hauptverfasser: Santos, Mafalda, Pereira, Patricia M., Varanda, A. Sofia, Carvalho, Joana, Azevedo, Mafalda, Mateus, Denisa D., Mendes, Nuno, Oliveira, Patricia, Trindade, Fábio, Pinto, Marta Teixeira, Bordeira-Carriço, Renata, Carneiro, Fátima, Vitorino, Rui, Oliveira, Carla, Santos, Manuel A. S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2018
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6152441/
https://ncbi.nlm.nih.gov/pubmed/29558247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15476286.2018.1454244
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