Rescue of wild-type E-cadherin expression from nonsense-mutated cancer cells by a suppressor-tRNA

Hereditary diffuse gastric cancer (HDGC) syndrome, although rare, is highly penetrant at an early age, and is severe and incurable because of ineffective screening tools and therapy. Approximately 45% of HDGC families carry germline CDH1/E-cadherin alterations, 20% of which are nonsense leading to p...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Bordeira-Carriço, Renata, Ferreira, Daniel, Mateus, Denisa D, Pinheiro, Hugo, Pêgo, Ana Paula, Santos, Manuel AS, Oliveira, Carla
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2014
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135406/
https://ncbi.nlm.nih.gov/pubmed/24424122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ejhg.2013.292
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk