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Rescue of wild-type E-cadherin expression from nonsense-mutated cancer cells by a suppressor-tRNA
Hereditary diffuse gastric cancer (HDGC) syndrome, although rare, is highly penetrant at an early age, and is severe and incurable because of ineffective screening tools and therapy. Approximately 45% of HDGC families carry germline CDH1/E-cadherin alterations, 20% of which are nonsense leading to p...
Tallennettuna:
| Päätekijät: | , , , , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Nature Publishing Group
2014
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4135406/ https://ncbi.nlm.nih.gov/pubmed/24424122 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ejhg.2013.292 |
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