Rescue of nonsense mutations by amlexanox in human cells

BACKGROUND: Nonsense mutations are at the origin of many cancers and inherited genetic diseases. The consequence of nonsense mutations is often the absence of mutant gene expression due to the activation of an mRNA surveillance mechanism called nonsense-mediated mRNA decay (NMD). Strategies to rescu...

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Hauptverfasser: Gonzalez-Hilarion, Sara, Beghyn, Terence, Jia, Jieshuang, Debreuck, Nadège, Berte, Gonzague, Mamchaoui, Kamel, Mouly, Vincent, Gruenert, Dieter C, Déprez, Benoit, Lejeune, Fabrice
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2012
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3562214/
https://ncbi.nlm.nih.gov/pubmed/22938201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1172-7-58
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