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Insights into the Effect of the G245S Single Point Mutation on the Structure of p53 and the Binding of the Protein to DNA

The transcription factor p53 is a potent tumor suppressor dubbed as the “guardian of the genome” because of its ability to orchestrate protective biological outputs in response to a variety of oncogenic stresses. Mutation and thus inactivation of p53 can be found in 50% of human tumors. The majority...

詳細記述

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書誌詳細
出版年:Molecules
主要な著者: Lepre, Marco Gaetano, Omar, Sara Ibrahim, Grasso, Gianvito, Morbiducci, Umberto, Deriu, Marco Agostino, Tuszynski, Jack A.
フォーマット: Artigo
言語:Inglês
出版事項: MDPI 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6152093/
https://ncbi.nlm.nih.gov/pubmed/28813011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules22081358
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