Use of Protein Kinase Focused Compound Libraries for the Discovery of New Inositol Phosphate Kinase Inhibitors

Inositol hexakisphosphate kinases (IP6Ks) regulate a myriad of cellular processes, not only through their catalytic activity which synthesizes InsP(7), a multifunctional inositol pyrophosphate signaling molecule, but also through protein-protein interactions. To further study the enzymatic function...

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Bibliographic Details
Published in:SLAS Discov
Main Authors: Puhl-Rubio, Ana C., Stashko, Michael A., Wang, Huanchen, Hardy, P. Brian, Tyagi, Vikas, Li, Bing, Wang, Xiaodong, Kireev, Dmitri, Jessen, Henning J., Frye, Stephen V., Shears, Stephen B., Pearce, Kenneth H.
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6148399/
https://ncbi.nlm.nih.gov/pubmed/29842835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2472555218775323
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