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Structural features of human inositol phosphate multikinase rationalize its inositol phosphate kinase and phosphoinositide 3-kinase activities
Human inositol phosphate multikinase (HsIPMK) critically contributes to intracellular signaling through its inositol-1,4,5-trisphosphate (Ins(1,4,5)P(3)) 3-kinase and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P(2)) 3-kinase activities. This catalytic profile is not conserved; orthologs from...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5672042/ https://ncbi.nlm.nih.gov/pubmed/28882892 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.801845 |
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