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Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding

Inositol pyrophosphates (such as IP7 and IP8) are multifunctional signaling molecules that regulate diverse cellular activities. Inositol pyrophosphates have ‘high-energy’ phosphoanhydride bonds, so their enzymatic synthesis requires that a substantial energy barrier to the transition state be overc...

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Bibliografiska uppgifter
Huvudupphovsmän: Wang, Huanchen, Falck, J R, Hall, Traci M Tanaka, Shears, Stephen B
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2011
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3923263/
https://ncbi.nlm.nih.gov/pubmed/22119861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.733
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