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Isolation and Characterization of a Dihydrofolate Reductase Gene Mutation in Methotrexate-Resistant Drosophila Cells
Stepwise increases in methotrexate (MTX) concentration over a 4-year period led to the selection of a highly drug-resistant (2 × 10(-4) M MTX) Drosophila cell line. Uptake experiments with [(3)H]MTX showed a slightly lower level of intracellular MTX in the resistant S3Mtx cells than in the susceptib...
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| Publicado no: | Gene Expr |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cognizant Communication Corporation
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6148270/ https://ncbi.nlm.nih.gov/pubmed/9196078 |
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