Isolation and Characterization of a Dihydrofolate Reductase Gene Mutation in Methotrexate-Resistant Drosophila Cells

Stepwise increases in methotrexate (MTX) concentration over a 4-year period led to the selection of a highly drug-resistant (2 × 10(-4) M MTX) Drosophila cell line. Uptake experiments with [(3)H]MTX showed a slightly lower level of intracellular MTX in the resistant S3Mtx cells than in the susceptib...

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Vydáno v:Gene Expr
Hlavní autoři: Hao, Hong, Tyshenko, Michael G., Walker, Virginia K.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cognizant Communication Corporation 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6148270/
https://ncbi.nlm.nih.gov/pubmed/9196078
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