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Identification and characterization of a gene that is coamplified with dihydrofolate reductase in a methotrexate-resistant CHO cell line.

As part of an effort to characterize the spatial and functional relationships among genetic elements within the amplified dihydrofolate reductase (DHFR) domain in Chinese hamster cells, we have used a variation of the differential hybridization approach to identify cDNA clones whose genes are coampl...

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Main Authors: Foreman, P K, Hamlin, J L
格式: Artigo
語言:Inglês
出版: 1989
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC362704/
https://ncbi.nlm.nih.gov/pubmed/2725490
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