TGF-β inhibits alveolar protein transport by promoting shedding, regulated intramembrane proteolysis, and transcriptional downregulation of megalin

Disruption of the alveolar-capillary barrier is a hallmark of acute respiratory distress syndrome (ARDS) that leads to the accumulation of protein-rich edema in the alveolar space, often resulting in comparable protein concentrations in alveolar edema and plasma and causing deleterious remodeling. P...

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Publicado en:Am J Physiol Lung Cell Mol Physiol
Autores principales: Mazzocchi, Luciana C., Vohwinkel, Christine U., Mayer, Konstantin, Herold, Susanne, Morty, Rory E., Seeger, Werner, Vadász, István
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2017
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6148198/
https://ncbi.nlm.nih.gov/pubmed/28705909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00569.2016
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