Hypercapnia Impairs Na,K-ATPase Function by Inducing Endoplasmic Reticulum Retention of the β-Subunit of the Enzyme in Alveolar Epithelial Cells

Alveolar edema, impaired alveolar fluid clearance, and elevated CO(2) levels (hypercapnia) are hallmarks of the acute respiratory distress syndrome (ARDS). This study investigated how hypercapnia affects maturation of the Na,K-ATPase (NKA), a key membrane transporter, and a cell adhesion molecule in...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Kryvenko, Vitalii, Wessendorf, Miriam, Morty, Rory E., Herold, Susanne, Seeger, Werner, Vagin, Olga, Dada, Laura A., Sznajder, Jacob I., Vadász, István
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7073107/
https://ncbi.nlm.nih.gov/pubmed/32098115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21041467
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