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Hypercapnia Impairs Na,K-ATPase Function by Inducing Endoplasmic Reticulum Retention of the β-Subunit of the Enzyme in Alveolar Epithelial Cells

Alveolar edema, impaired alveolar fluid clearance, and elevated CO(2) levels (hypercapnia) are hallmarks of the acute respiratory distress syndrome (ARDS). This study investigated how hypercapnia affects maturation of the Na,K-ATPase (NKA), a key membrane transporter, and a cell adhesion molecule in...

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Bibliografiske detaljer
Udgivet i:Int J Mol Sci
Main Authors: Kryvenko, Vitalii, Wessendorf, Miriam, Morty, Rory E., Herold, Susanne, Seeger, Werner, Vagin, Olga, Dada, Laura A., Sznajder, Jacob I., Vadász, István
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7073107/
https://ncbi.nlm.nih.gov/pubmed/32098115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21041467
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