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Co-evolutionary fitness landscapes for sequence design

Efficient and accurate models to predict the fitness of a sequence would be extremely valuable in protein design. We have explored the use of statistical potentials for the coevolutionary fitness landscape, extracted from known protein sequences, in conjuction with Monte Carlo simulations, as a tool...

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Bibliographische Detailangaben
Veröffentlicht in:Angew Chem Int Ed Engl
Hauptverfasser: Tian, Pengfei, Louis, John M., Baber, James L., Aniana, Annie, Best, Robert B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6147258/
https://ncbi.nlm.nih.gov/pubmed/29512300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201713220
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