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Co-evolutionary fitness landscapes for sequence design
Efficient and accurate models to predict the fitness of a sequence would be extremely valuable in protein design. We have explored the use of statistical potentials for the coevolutionary fitness landscape, extracted from known protein sequences, in conjuction with Monte Carlo simulations, as a tool...
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| Publicado no: | Angew Chem Int Ed Engl |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6147258/ https://ncbi.nlm.nih.gov/pubmed/29512300 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201713220 |
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