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Potts Hamiltonian models of protein co-variation, free energy landscapes, and evolutionary fitness
Potts Hamiltonian models of protein sequence co-variation are statistical models constructed from the pair correlations observed in a multiple sequence alignment (MSA) of a protein family. These models are powerful because they capture higher order correlations induced by mutations evolving under co...
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| Publicado no: | Curr Opin Struct Biol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5869684/ https://ncbi.nlm.nih.gov/pubmed/27870991 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.sbi.2016.11.004 |
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