Exploring the Free-Energy Landscape and Thermodynamics of Protein-Protein Association

We report the free-energy landscape and thermodynamics of the protein-protein association responsible for the drug-induced multimerization of HIV-1 integrase (IN). Allosteric HIV-1 integrase inhibitors promote aberrant IN multimerization by bridging IN-IN intermolecular interactions. However, the th...

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Detalhes bibliográficos
Publicado no:Biophys J
Main Authors: Tse, Celine, Wickstrom, Lauren, Kvaratskhelia, Mamuka, Gallicchio, Emilio, Levy, Ronald, Deng, Nanjie
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2020
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7499063/
https://ncbi.nlm.nih.gov/pubmed/32877664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2020.08.005
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