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Exploring the Free-Energy Landscape and Thermodynamics of Protein-Protein Association
We report the free-energy landscape and thermodynamics of the protein-protein association responsible for the drug-induced multimerization of HIV-1 integrase (IN). Allosteric HIV-1 integrase inhibitors promote aberrant IN multimerization by bridging IN-IN intermolecular interactions. However, the th...
Shranjeno v:
| izdano v: | Biophys J |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
The Biophysical Society
2020
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7499063/ https://ncbi.nlm.nih.gov/pubmed/32877664 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2020.08.005 |
| Oznake: |
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