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The Linear Interaction Energy Method for the Prediction of Protein Stability Changes Upon Mutation

The coupling of protein energetics and sequence changes is a critical aspect of computational protein design, as well as for the understanding of protein evolution, human disease, and drug resistance. In order to study the molecular basis for this coupling, computational tools must be sufficiently a...

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Detalhes bibliográficos
Main Authors: Wickstrom, Lauren, Gallicchio, Emilio, Levy, Ronald M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3240711/
https://ncbi.nlm.nih.gov/pubmed/22038697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.23168
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