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NeEMO: a method using residue interaction networks to improve prediction of protein stability upon mutation
BACKGROUND: The rapid growth of un-annotated missense variants poses challenges requiring novel strategies for their interpretation. From the thermodynamic point of view, amino acid changes can lead to a change in the internal energy of a protein and induce structural rearrangements. This is of grea...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
BioMed Central
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4083412/ https://ncbi.nlm.nih.gov/pubmed/25057121 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-15-S4-S7 |
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