Pol-Driven Replicative Capacity Impacts Disease Progression in HIV-1 Subtype C Infection

CD8(+) T cell-mediated escape mutations in Gag can reduce HIV-1 replication capacity (RC) and alter disease progression, but less is known about immune-mediated attenuation in other HIV-1 proteins. We generated 487 recombinant viruses encoding RT-integrase from individuals with chronic (n = 406) and...

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Détails bibliographiques
Publié dans:J Virol
Auteurs principaux: Ojwach, Doty B. A., MacMillan, Daniel, Reddy, Tarylee, Novitsky, Vladimir, Brumme, Zabrina L., Brockman, Mark A., Ndung'u, Thumbi, Mann, Jaclyn K.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2018
Sujets:
Pathogenesis and Immunity
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6146804/
https://ncbi.nlm.nih.gov/pubmed/29997209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00811-18
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