BTC1.04 Genomic profiling of IDH-wildtype and IDH-mutant initial and matched recurrent glioblastomas reveals clinically actionable mutations (e.g. BRCA1/2) and resistance signatures

BACKGROUND: Glioblastomas account for 90% of all adult brain tumours. Patient survival remains low because treatments are ineffective against this lethal disease. Understanding the genes and pathways altered in subtypes is necessary for therapeutic intervention. MATERIAL AND METHODS: Tumours from 41...

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Foilsithe in:Neuro Oncol
Main Authors: McInerney, C E, Ellis, H P, Schrimpf, D, Sahm, F, Stupnikov, A, Wadsley, M, Wragg, C, White, P, Prise, K M, McArt, D G, Kurian, K M
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2018
Ábhair:
Oral Presentations
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6144622/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy139.003
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