BTC1.04 Genomic profiling of IDH-wildtype and IDH-mutant initial and matched recurrent glioblastomas reveals clinically actionable mutations (e.g. BRCA1/2) and resistance signatures

BACKGROUND: Glioblastomas account for 90% of all adult brain tumours. Patient survival remains low because treatments are ineffective against this lethal disease. Understanding the genes and pathways altered in subtypes is necessary for therapeutic intervention. MATERIAL AND METHODS: Tumours from 41...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: McInerney, C E, Ellis, H P, Schrimpf, D, Sahm, F, Stupnikov, A, Wadsley, M, Wragg, C, White, P, Prise, K M, McArt, D G, Kurian, K M
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Oral Presentations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6144622/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy139.003
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