mRNA-binding protein tristetraprolin is essential for cardiac response to iron deficiency by regulating mitochondrial function

Cells respond to iron deficiency by activating iron-regulatory proteins to increase cellular iron uptake and availability. However, it is not clear how cells adapt to conditions when cellular iron uptake does not fully match iron demand. Here, we show that the mRNA-binding protein tristetraprolin (T...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Sato, Tatsuya, Chang, Hsiang-Chun, Bayeva, Marina, Shapiro, Jason S., Ramos-Alonso, Lucia, Kouzu, Hidemichi, Jiang, Xinghang, Liu, Ting, Yar, Sumeyye, Sawicki, Konrad T., Chen, Chunlei, Martínez-Pastor, María Teresa, Stumpo, Deborah J., Schumacker, Paul T., Blackshear, Perry J., Ben-Sahra, Issam, Puig, Sergi, Ardehali, Hossein
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6142244/
https://ncbi.nlm.nih.gov/pubmed/29915044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1804701115
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