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Hepatic tristetraprolin promotes insulin resistance through RNA destabilization of FGF21
The role of posttranscriptional metabolic gene regulatory programs in diabetes is not well understood. Here, we show that the RNA-binding protein tristetraprolin (TTP) is reduced in the livers of diabetic mice and humans and is transcriptionally induced in response to insulin treatment in murine liv...
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| Wydane w: | JCI Insight |
|---|---|
| Główni autorzy: | , , , , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Society for Clinical Investigation
2018
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6124529/ https://ncbi.nlm.nih.gov/pubmed/29997282 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.95948 |
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