Hepatic tristetraprolin promotes insulin resistance through RNA destabilization of FGF21

The role of posttranscriptional metabolic gene regulatory programs in diabetes is not well understood. Here, we show that the RNA-binding protein tristetraprolin (TTP) is reduced in the livers of diabetic mice and humans and is transcriptionally induced in response to insulin treatment in murine liv...

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Dades bibliogràfiques
Publicat a:JCI Insight
Autors principals: Sawicki, Konrad T., Chang, Hsiang-Chun, Shapiro, Jason S., Bayeva, Marina, De Jesus, Adam, Finck, Brian N., Wertheim, Jason A., Blackshear, Perry J., Ardehali, Hossein
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6124529/
https://ncbi.nlm.nih.gov/pubmed/29997282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.95948
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