IL-6 and CXCL8 mediate osteosarcoma-lung interactions critical to metastasis

Osteosarcoma (OS), a malignant tumor of bone, kills through aggressive metastatic spread almost exclusively to the lung. Mechanisms driving this tropism for lung tissue remain unknown, though likely invoke specific interactions between tumor cells and other cells within the lung metastatic niche. Ab...

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Vydáno v:JCI Insight
Hlavní autoři: Gross, Amy C., Cam, Hakan, Phelps, Doris A., Saraf, Amanda J., Bid, Hemant K., Cam, Maren, London, Cheryl A., Winget, Sarah A., Arnold, Michael A., Brandolini, Laura, Mo, Xiaokui, Hinckley, John M., Houghton, Peter J., Roberts, Ryan D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6141177/
https://ncbi.nlm.nih.gov/pubmed/30135299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.99791
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