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IL-6 and CXCL8 mediate osteosarcoma-lung interactions critical to metastasis

Osteosarcoma (OS), a malignant tumor of bone, kills through aggressive metastatic spread almost exclusively to the lung. Mechanisms driving this tropism for lung tissue remain unknown, though likely invoke specific interactions between tumor cells and other cells within the lung metastatic niche. Ab...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Gross, Amy C., Cam, Hakan, Phelps, Doris A., Saraf, Amanda J., Bid, Hemant K., Cam, Maren, London, Cheryl A., Winget, Sarah A., Arnold, Michael A., Brandolini, Laura, Mo, Xiaokui, Hinckley, John M., Houghton, Peter J., Roberts, Ryan D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6141177/
https://ncbi.nlm.nih.gov/pubmed/30135299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.99791
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