Mutational signatures associated with tobacco smoking in human cancer

Tobacco smoking increases the risk of at least 17 classes of cancer. We analyzed somatic mutations and DNA methylation in 5,243 cancers of types for which tobacco smoking confers an elevated risk. Smoking is associated with increased mutation burdens of multiple distinct mutational signatures, which...

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Udgivet i:Science
Main Authors: Alexandrov, Ludmil B., Ju, Young Seok, Haase, Kerstin, Van Loo, Peter, Martincorena, Iñigo, Nik-Zainal, Serena, Totoki, Yasushi, Fujimoto, Akihiro, Nakagawa, Hidewaki, Shibata, Tatsuhiro, Campbell, Peter J., Vineis, Paolo, Phillips, David H., Stratton, Michael R.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6141049/
https://ncbi.nlm.nih.gov/pubmed/27811275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aag0299
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