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Prespliceosome structure provides insights into spliceosome assembly and regulation

The spliceosome catalyzes the excision of introns from pre-mRNA in two steps, branching and exon ligation, and is assembled from five small nuclear ribonucleoprotein particles (snRNPs; U1, U2, U4, U5, U6) and numerous non-snRNP factors1. For branching, the intron 5'-splice site (5'SS) and...

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Bibliografski detalji
Izdano u:Nature
Glavni autori: Plaschka, Clemens, Lin, Pei-Chun, Charenton, Clément, Nagai, Kiyoshi
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6141012/
https://ncbi.nlm.nih.gov/pubmed/29995849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0323-8
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