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Prespliceosome structure provides insights into spliceosome assembly and regulation
The spliceosome catalyzes the excision of introns from pre-mRNA in two steps, branching and exon ligation, and is assembled from five small nuclear ribonucleoprotein particles (snRNPs; U1, U2, U4, U5, U6) and numerous non-snRNP factors1. For branching, the intron 5'-splice site (5'SS) and...
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| Publicado no: | Nature |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6141012/ https://ncbi.nlm.nih.gov/pubmed/29995849 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0323-8 |
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