Combined use of CDK4/6 and mTOR inhibitors induce synergistic growth arrest of diffuse intrinsic pontine glioma cells via mutual downregulation of mTORC1 activity

BACKGROUND: Diffuse intrinsic pontine glioma (DIPG) is a lethal type of pediatric brain tumor that is resistant to conventional chemotherapies. Palbociclib is a putative novel DIPG treatment that restricts the proliferation of rapidly dividing cancer cells via selective inhibition of cyclin-dependen...

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Detalhes bibliográficos
Publicado no:Cancer Manag Res
Main Authors: Asby, Daniel J, Killick-Cole, Clare L, Boulter, Lisa J, Singleton, William GB, Asby, Claire A, Wyatt, Marcella J, Barua, Neil U, Bienemann, Alison S, Gill, Steven S
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2018
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6140749/
https://ncbi.nlm.nih.gov/pubmed/30254491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/CMAR.S167095
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