Repurposing the anti-epileptic drug sodium valproate as an adjuvant treatment for diffuse intrinsic pontine glioma

Targeting epigenetic changes in diffuse intrinsic pontine glioma (DIPG) may provide a novel treatment option for patients. This report demonstrates that sodium valproate, a histone deacetylase inhibitor (HDACi), can increase the cytotoxicity of carboplatin in an additive and synergistic manner in DI...

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Bibliographic Details
Published in:PLoS One
Main Authors: Killick-Cole, Clare L., Singleton, William G. B., Bienemann, Alison S., Asby, Daniel J., Wyatt, Marcella J., Boulter, Lisa J., Barua, Neil U., Gill, Steven S.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2017
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5444593/
https://ncbi.nlm.nih.gov/pubmed/28542253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0176855
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