TRTH-19. PRECLINICAL ANALYSIS OF SODIUM VALPROATE FOR THE TREATMENT OF DIPG BY CONVECTION ENHANCED DELIVERY

There is a significant need to develop new treatment strategies to improve the prognosis of DIPG patients. We have previously shown that the HDAC inhibitor, sodium valproate (VPA), reduces the viability of DIPG cells in vitro. Whilst, VPA does cross the blood brain barrier, only 15% of serum concent...

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發表在:Neuro Oncol
Main Authors: Killick-Cole, Clare, Bienemann, Ali, Asby, Daniel, Singleton, William, Wyatt, Marcella, Boulter, Lisa, Barua, Neil, Gill, Steven
格式: Artigo
語言:Inglês
出版: Oxford University Press 2017
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5475205/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox083.230
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