TRTH-19. PRECLINICAL ANALYSIS OF SODIUM VALPROATE FOR THE TREATMENT OF DIPG BY CONVECTION ENHANCED DELIVERY

There is a significant need to develop new treatment strategies to improve the prognosis of DIPG patients. We have previously shown that the HDAC inhibitor, sodium valproate (VPA), reduces the viability of DIPG cells in vitro. Whilst, VPA does cross the blood brain barrier, only 15% of serum concent...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Killick-Cole, Clare, Bienemann, Ali, Asby, Daniel, Singleton, William, Wyatt, Marcella, Boulter, Lisa, Barua, Neil, Gill, Steven
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5475205/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox083.230
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