TRTH-19. PRECLINICAL ANALYSIS OF SODIUM VALPROATE FOR THE TREATMENT OF DIPG BY CONVECTION ENHANCED DELIVERY

There is a significant need to develop new treatment strategies to improve the prognosis of DIPG patients. We have previously shown that the HDAC inhibitor, sodium valproate (VPA), reduces the viability of DIPG cells in vitro. Whilst, VPA does cross the blood brain barrier, only 15% of serum concent...

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Bibliografische gegevens
Gepubliceerd in:Neuro Oncol
Hoofdauteurs: Killick-Cole, Clare, Bienemann, Ali, Asby, Daniel, Singleton, William, Wyatt, Marcella, Boulter, Lisa, Barua, Neil, Gill, Steven
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5475205/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox083.230
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