Ursodeoxycholic acid protects against intestinal barrier breakdown by promoting enterocyte migration via EGFR- and COX-2-dependent mechanisms

The intestinal barrier is often disrupted in disease states, and intestinal barrier failure leads to sepsis. Ursodeoxycholic acid (UDCA) is a bile acid that may protect the intestinal barrier. We hypothesized that UDCA would protect the intestinal epithelium in injury models. To test this hypothesis...

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Detalhes bibliográficos
Publicado no:Am J Physiol Gastrointest Liver Physiol
Main Authors: Golden, Jamie M., Escobar, Oswaldo H., Nguyen, Michelle V. L., Mallicote, Michael U., Kavarian, Patil, Frey, Mark R., Gayer, Christopher P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6139640/
https://ncbi.nlm.nih.gov/pubmed/29672156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00354.2017
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