Intestinal genetic inactivation of caspase-8 diminishes migration of enterocytes

AIM: To verify the hypothesis that caspase-8 (Casp8), which regulates cellular apoptosis and necroptosis, is critically involved in enterocyte migration. METHODS: Casp8-silenced Caco2 cells were used in migration assays. In addition, enterocyte-specific Casp8 heterozygous (Casp8(+/∆int)) or homozygo...

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Vydáno v:World J Gastroenterol
Hlavní autoři: Kaemmerer, Elke, Kuhn, Paula, Schneider, Ursula, Jeon, Min Kyung, Klaus, Christina, Schiffer, Miriam, Weisner, Danika, Liedtke, Christian, Jäkel, Jörg, Kennes, Lieven Nils, Hilgers, Ralf-Dieter, Wagner, Norbert, Gassler, Nikolaus
Médium: Artigo
Jazyk:Inglês
Vydáno: Baishideng Publishing Group Inc 2015
Témata:
Basic Study
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4402296/
https://ncbi.nlm.nih.gov/pubmed/25914458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v21.i15.4499
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