Klf4 has an unexpected protective role in perivascular cells within the microvasculature

Recent smooth muscle cell (SMC) lineage-tracing studies have revealed that SMCs undergo remarkable changes in phenotype during development of atherosclerosis. Of major interest, we demonstrated that Kruppel-like factor 4 (KLF4) in SMCs is detrimental for overall lesion pathogenesis, in that SMC-spec...

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Pubblicato in:Am J Physiol Heart Circ Physiol
Autori principali: Haskins, Ryan M., Nguyen, Anh T., Alencar, Gabriel F., Billaud, Marie, Kelly-Goss, Molly R., Good, Miranda E., Bottermann, Katharina, Klibanov, Alexander L., French, Brent A., Harris, Thurl E., Peirce, Shayn M., Isakson, Brant E., Owens, Gary K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6139624/
https://ncbi.nlm.nih.gov/pubmed/29631369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00084.2018
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