Perivascular cell-specific knockout of the stem cell pluripotency gene Oct4 inhibits angiogenesis

The stem cell pluripotency factor Oct4 serves a critical protective role during atherosclerotic plaque development by promoting smooth muscle cell (SMC) investment. Here, we show using Myh11-CreER(T2) lineage-tracing with inducible SMC and pericyte (SMC-P) knockout of Oct4 that Oct4 regulates periva...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Hess, Daniel L., Kelly-Goss, Molly R., Cherepanova, Olga A., Nguyen, Anh T., Baylis, Richard A., Tkachenko, Svyatoslav, Annex, Brian H., Peirce, Shayn M., Owens, Gary K.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6393549/
https://ncbi.nlm.nih.gov/pubmed/30814500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08811-z
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