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Protection of telomeres 1 proteins POT1a and POT1b can repress ATR signaling by RPA exclusion, but binding to CST limits ATR repression by POT1b

Comprised of telomeric TTAGGG repeats and shelterin, telomeres ensure that the natural ends of chromosomes remain impervious to the DNA damage response. Telomeres carry a long constitutive 3′ overhang that can bind replication protein A (RPA) and activate the ATR Ser/Thr kinase (ATR), which induces...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Kratz, Katja, de Lange, Titia
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6139565/
https://ncbi.nlm.nih.gov/pubmed/30082315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004598
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