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Protection of telomeres 1 proteins POT1a and POT1b can repress ATR signaling by RPA exclusion, but binding to CST limits ATR repression by POT1b
Comprised of telomeric TTAGGG repeats and shelterin, telomeres ensure that the natural ends of chromosomes remain impervious to the DNA damage response. Telomeres carry a long constitutive 3′ overhang that can bind replication protein A (RPA) and activate the ATR Ser/Thr kinase (ATR), which induces...
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| Udgivet i: | J Biol Chem |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6139565/ https://ncbi.nlm.nih.gov/pubmed/30082315 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004598 |
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