Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis

Akt is a critical protein kinase that drives cancer proliferation, modulates metabolism, and is activated by C-terminal phosphorylation. The current structural model for Akt activation by C-terminal phosphorylation has centered on intramolecular interactions between the C-terminal tail and the N-lob...

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Bibliografische gegevens
Gepubliceerd in:Cell
Hoofdauteurs: Chu, Nam, Salguero, Antonieta L., Liu, Albert Z., Chen, Zan, Dempsey, Daniel R., Ficarro, Scott B., Alexander, William M., Marto, Jarrod A., Li, Yana, Amzel, L. Mario, Gabelli, Sandra B., Cole, Philip A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6139374/
https://ncbi.nlm.nih.gov/pubmed/30078705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.07.003
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