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The structural determinants of PH domain-mediated regulation of Akt revealed by segmental labeling
Akt is a critical protein kinase that governs cancer cell growth and metabolism. Akt appears to be autoinhibited by an intramolecular interaction between its N-terminal pleckstrin homology (PH) domain and kinase domain, which is relieved by C-tail phosphorylation, but the precise molecular mechanism...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7438110/ https://ncbi.nlm.nih.gov/pubmed/32744507 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.59151 |
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