Phosphorylation-mediated PTEN conformational closure and deactivation revealed with protein semisynthesis

The tumor suppressor PIP(3) phosphatase PTEN is phosphorylated on four clustered Ser/Thr on its C-terminal tail (aa 380–385) and these phosphorylations are proposed to induce a reduction in PTEN’s plasma membrane recruitment. How these phosphorylations affect the structure and enzymatic function of...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Bolduc, David, Rahdar, Meghdad, Tu-Sekine, Becky, Sivakumaren, Sindhu Carmen, Raben, Daniel, Amzel, L Mario, Devreotes, Peter, Gabelli, Sandra B, Cole, Philip
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2013
Assuntos:
Biochemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3707082/
https://ncbi.nlm.nih.gov/pubmed/23853711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.00691
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados