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A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN
The PI 3-phosphatase PTEN (phosphatase and tensin homologue deleted on chromosome 10), one of the most important tumor suppressors, must associate with the plasma membrane to maintain appropriate steady-state levels of phosphatidylinositol 3,4,5-triphosphate. Yet the mechanism of membrane binding ha...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2009
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2626728/ https://ncbi.nlm.nih.gov/pubmed/19114656 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0811212106 |
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