Lipin-1 regulation of phospholipid synthesis maintains endoplasmic reticulum homeostasis and is critical for triple-negative breast cancer cell survival

Cancer cells reprogram their metabolism to increase the synthesis of macromolecules for rapid proliferation. Compared to fatty acids, much less is known about the synthesis of phospholipids, which is essential for membrane biogenesis in cancer cells. We found that LPIN1, which encodes lipin-1, a pho...

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Veröffentlicht in:FASEB J
Hauptverfasser: He, Jingquan, Zhang, Feng, Tay, Li Wei Rachel, Boroda, Salome, Nian, Weiqi, Levental, Kandice R., Levental, Ilya, Harris, Thurl E., Chang, Jeffrey T., Du, Guangwei
Format: Artigo
Sprache:Inglês
Veröffentlicht: Federation of American Societies for Experimental Biology 2017
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6137500/
https://ncbi.nlm.nih.gov/pubmed/28347999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201601353R
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