Lipin-1 regulation of phospholipid synthesis maintains endoplasmic reticulum homeostasis and is critical for triple-negative breast cancer cell survival

Cancer cells reprogram their metabolism to increase the synthesis of macromolecules for rapid proliferation. Compared to fatty acids, much less is known about the synthesis of phospholipids, which is essential for membrane biogenesis in cancer cells. We found that LPIN1, which encodes lipin-1, a pho...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: He, Jingquan, Zhang, Feng, Tay, Li Wei Rachel, Boroda, Salome, Nian, Weiqi, Levental, Kandice R., Levental, Ilya, Harris, Thurl E., Chang, Jeffrey T., Du, Guangwei
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6137500/
https://ncbi.nlm.nih.gov/pubmed/28347999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201601353R
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