Lipin 2/3 phosphatidic acid phosphatases maintain phospholipid homeostasis to regulate chylomicron synthesis

The lipin phosphatidic acid phosphatase (PAP) enzymes are required for triacylglycerol (TAG) synthesis from glycerol 3-phosphate in most mammalian tissues. The 3 lipin proteins (lipin 1, lipin 2, and lipin 3) each have PAP activity, but have distinct tissue distributions, with lipin 1 being the pred...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Zhang, Peixiang, Csaki, Lauren S., Ronquillo, Emilio, Baufeld, Lynn J., Lin, Jason Y., Gutierrez, Alexis, Dwyer, Jennifer R., Brindley, David N., Fong, Loren G., Tontonoz, Peter, Young, Stephen G., Reue, Karen
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2018
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6307960/
https://ncbi.nlm.nih.gov/pubmed/30507612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI122595
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